Take that, Lou Gehrig

For those interested in solving ALS (aka Lou Gehrig’s disease), last week was pretty good. While fewer than 20,000 people each year in the US are diagnosed with ALS, the impact of the disease is devastating. Researchers from Syracuse University, St. Jude’s, and SUNY Update Medical Center published a paper in Molecular Cell describing how ubiquitin eliminates droplets of Ubiquilin-2 (UBQLN2) in solution. This is important because UBQLN2 is found in motor neuron inclusions of ALS patients. The hope is that the research can lead to a better understanding of ALS’ molecular mechanisms. In a separate study, NIH-funded researchers at Stanford “used the gene editing tool CRISPR to rapidly identify genes in the human genome that might modify the severity of amyotrophic lateral sclerosis (ALS) caused by mutations in a gene called C9orf72.” Go get ’em. We couldn’t say it any better: #ALSsucks