What do you get when you cross the Red Hot Chili Peppers with Richard Simmons? Well, you get the potential for an anti-obesity drug. Researchers at the University of Wyoming School of Pharmacy have studied a new oral drug (Metabocin) based on capsaicin—the compound that gives chili peppers their spicy burn— that caused long-term weight loss and improved metabolic health in mice eating a high-fat diet. Yep, the studies are in the preclinical phase, but so far they’ve found success targeting receptors called TRPV1 (transient receptor potential vanilloid subfamily 1) that are found in high numbers in fat cells. Can’t one simply ingest a bottle of Tabasco and lose weight? Nope, the capsaicin was modified for proper absorption and sustained release. Ok, second chance, you know you want to click on the Richard Simmons link.