5. Dolla, dolla bills, yo!

According to QuintilesIMS, total consumer drug spend is estimated to top $1.5 trillion by 2021. That’s a lot of green. It’s a brave new healthy world out there and while the cash may well roll in for pharma companies, it’s not all fun and games. In the words of the not-so-immortal Biggie Smalls, “mo money mo problems.” While much of it will surely go toward development of the projected 45 new launches per year, these kinds of figures will not go unnoticed in popular media and political circles. Prepare for more pricing pressure and calls to demonstrate product value through health outcomes studies, comparative effectiveness research, and numerous other versions of payers telling pharma to “prove it.”