While many of us associate the shakes with too much caffeine, research has shown that higher caffeine consumption is associated with reduced motor disability from Parkinson’s disease and slowed progression of non-motor symptoms. While the cause of Parkinson’s is still unknown, studies of the brains of PD patients show the alpha-synuclein protein misfolds causing clumps called Lewy bodies which impair motor control. With this knowledge, scientists sought a way to stop the protein from misfolding. They created a “caffeine scaffold” to build eight compounds that they tested on a yeast model of Parkinson’s disease. Two caffeine-based compounds were found to bind to a-synuclein and stop the protein from forming clumps. Great news for coffee addicts and the pharmaceutical industry, which previously managed symptoms but couldn’t slow PD progression.