Strange but true. Using a molecule structurally similar to opioids, researchers at The Scripps Research Institute successfully blunted the effects of oxycodone and hydrocodone in mice. Specifically, the drug binds to the opioid molecule and prevents it from ever making its way to the brain, limiting the user’s pain and euphoria responses to the drug. Such an intervention may be beneficial over other forms of treatment because it does not chemically alter the brain. The study also found that mice that received the vaccine took longer to overdose from high levels of opioid ingestion, which could mean more time for users who overdose from opioids to seek treatment.